Bioisosteres in Medicinal Chemistry; John Wiley & Sons Limited
14846 р.
- Издатель: John Wiley & Sons Limited
- ISBN: 9783527654338
- Книги: Медицина
- ID:5998177
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Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
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Издатель | John Wiley & Sons Limited |
ISBN | 978-3-527-65433-8 |
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Книги: Фармакология - издательство "John Wiley & Sons Limited"
Категория 11876 р. - 17815 р.